Gene trapping is a high-throughput approach that is used to introduce insertional mutations across an organism's genome.
Gene targeting is a biotechnological tool used to change the DNA sequence of an organism (hence it is a form of genome editing). It is based on the natural DNA-repair mechanism of homology directed repair (HDR), including homologous recombination....
Animal trapping, or simply trapping or ginning, is the use of a device to remotely catch and often kill an animal. Animals may be trapped for a variety of purposes, including for meat, fur/feathers, sport hunting, pest control, and wildlife...
An exon is any part of a gene that will form a part of the final mature RNA produced by that gene after introns have been removed by RNA splicing. The term exon refers to both the DNA sequence within a gene and to the corresponding sequence in RNA...
A knockout rat is a genetically engineered rat with a single gene turned off through a targeted mutation (gene trapping) used for academic and pharmaceutical research. Knockout rats can mimic human diseases and are important tools for studying gene...
Lexicon Pharmaceuticals, Inc. is a biopharmaceutical company developing treatments for human disease. The company was founded in 1995 in The Woodlands, Texas under the name Lexicon Genetics, Incorporated by co-founders Professor Allan Bradley, FRS...
ROSA26 is a locus used for constitutive, ubiquitous gene expression in mice. It was first isolated in 1991 by the group of Philippe Soriano in a gene-trap mutagenesis screen of embryonic stem cells (ESCs). Over 800 knock-in lines have been created...
An enhancer trap is a method in molecular biology. The enhancer trap construct contains a transposable element and a reporter gene. The first is necessary for (random) insertion in the genome, the latter is necessary for identification of the...
Bioluminescence is the production of light by an organism as the result of a chemiluminescence reaction. It occurs in a wide variety of organisms, including marine vertebrates and invertebrates, terrestrial arthropods such as fireflies, some fungi,...
Melissa Anne Haendel is an American bioinformaticist who is the Sarah Graham Kenan Distinguished Professor at the UNC School of Medicine. She is also the Director of Precision Health & Translational Informatics, deputy director of Computational...
